Corso di laurea magistrale in Chimica Clinica Forense e dello Sport

Learning the chemical structure-activity relationships of the compounds
and overview of the main biologically active compounds in the context of
doping in sport and abuse. Acquisition of skills relating to the
identification of pharmacologically active molecules and their
pharmacodynamic and pharmacokinetic properties

Acquisition of the concepts of bioactive molecule and its characterization
parameters

Written examination. The exam is devoted to the assessment of the knowledge, and related understanding of the program attained by the students. In addition, also knowledge and understanding of basic knowledge in Chemistry which should be necessary consider will be evaluated, as well as the use of a proper  scientific/technical language. Rating of thirty-mediated (with tolerance in excess) with that of module B.

Introduction: biological activity and toxicity of chemical compounds.
Molecular biochemistry. Cellular components; endogenous and
exogenous chemical compounds; biomacromolecules ; neurotransmitters,
hormones, and vitamins; receptors . Correlation between chemical,
physico-chemical and biological activity. Dose-response relationships.
Classification of receptors.
Pharmacodynamics: chemical bonding, intermolecular forces ionization,
interaction in solvents; classes of organic compounds and properties.
Pharmacokinetics. Absorption, transport and excretion of bioactive
compounds. Metabolic reactions, biotransformations and environmental
reactions. Toxicity: acute, chronic, reversible, irreversible, local, systemic,
independent, additive, synergistic and antagonistic. Toxicological
concepts.
Systematic description of the classes of drugs of abuse and doping:
Endogenous and synthetic anabolic steroids. Peptide hormones. Betaagonists.
Hormonal and metabolic modulators. Diuretics and masking.
Stimulants. Narcotics. Cannabinoids. Glucocorticosteroids. Alcohol.
Psychotomimetics. Anti-inflammatory and anti-histamine drugs.